Dysregulation of cerebral perfusion dynamics is associated with Alzheimer's disease.

ABSTRACT:

Introduction

A novel physio-marker, termed "cerebrovascular dynamics index" (CDI), was developed and evaluated in a multi-center National Institutes of Health (NIH)-funded study for improved diagnosis of mild cognitive impairment (MCI) and its transition to Alzheimer's disease (AD).

Methods

The CDI quantifies the regulation dynamics of cerebral perfusion and oxygenation (which adjust autonomously blood flow and oxygen delivery over time) through predictive dynamic modeling using relevant time-series data.

Results

Cross-sectional results demonstrated excellent diagnostic performance of CDI in differentiating 90 MCI/AD patients from 77 controls (area under the curve (AUC) =  0.96), which surpassed the commonly used biomarker of amyloid positron emission tomography-stand

SUBMITTER: Marmarelis V 

PROVIDER: S-EPMC12272300 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature