Involvement of ferroptosis in lipopolysaccharide-induced intestinal inflammation in broilers.

ABSTRACT: This study aimed to investigate whether lipopolysaccharide (LPS)-induced intestinal inflammation involves ferroptosis and its impact on broiler gut health. Two animal trials were conducted. In the first trial, 192 ROSS 308 broilers were randomly assigned to four groups and intraperitoneally injected with either 0.9 % sterile saline (control) or different doses of LPS (0.5, 1.0, and 5.0 mg/kg body weight) on days 16, 18, and 20. The results suggested that ferroptosis-related changes might occur in the intestine at the 5.0 mg/kg LPS dose, but the effects were not significant. Thus, a second trial was conducted with a shorter observation period. In this trial, 42 broilers were administered 5.0 mg/kg LPS or saline and sampled at 4, 8, and 24 h after the final injection to analyze ferroptosis-r

SUBMITTER: Chen YT 

PROVIDER: S-EPMC12272426 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature