Computationally Modeling the Physiologic Impact of the Ratio of Fats to Carbohydrates in the Diet on Intake Among Metabolically Healthy Adults.

ABSTRACT:

Background

When it comes to how effectively a diet can help reduce or maintain body weight, a key question is how that diet affects a person's hunger, satiety, and subsequent eating.

Objectives

This study aimed to analyze modeling, from a physiologic perspective, how varying the ratio of fats to carbohydrates in a diet impacts hunger, satiety, and subsequent eating among metabolically healthy adults.

Methods

We developed a model representing an adult, their dietary intake, gastrointestinal tract, hunger/satiety levels, and meal consumption. We simulated agents eating fixed ratios of macronutrients and measured their subsequent eating over 24 h driven by physiologic responses.

Results

When increasing the proportion of energy from fats relative to carbohydrates,

SUBMITTER: Martinez MF 

PROVIDER: S-EPMC12272436 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature