Sex Differences in Children and Adolescents With Hypertrophic Cardiomyopathy.

ABSTRACT:

Background

Sex differences have been described in adults with hypertrophic cardiomyopathy (HCM), but it is unknown if similar differences exist in childhood-onset disease.

Objectives

This study aimed to investigate the influence of biological sex on the clinical characteristics and outcomes of children with HCM.

Methods

An international retrospective cohort of patients diagnosed with nonsyndromic HCM ≤16 years was formed. Sex differences in baseline characteristics and clinical outcomes were investigated. Primary outcome was all-cause mortality or cardiac transplantation. Secondary outcomes include major arrhythmic cardiac event and heart failure event.

Results

Of 1,433 patients diagnosed at a median age of 11 years (IQR: 6-14), 471 (33.0%) were female. Althoug

SUBMITTER: Norrish G 

PROVIDER: S-EPMC12272437 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature