Genomic insights into biofilm-associated virulence in extensively drug-resistant <i>Acinetobacter baumannii</i>.

ABSTRACT: Acinetobacter baumannii is a notorious nosocomial pathogen known for its resistance to multiple antimicrobials, with biofilm formation contributing to its persistence in hospital environments. This study characterized biofilm-associated virulence genes in extensively drug-resistant (XDR) A. baumannii isolates from two distinct lineages, ST2 and ST25, to understand their roles in biofilm formation and antimicrobial resistance. From 135 non-repetitive multidrug-resistant (MDR) clinical isolates collected across Thailand, 15 XDR isolates (14 ST2 and 1 ST25) were selected for further analysis. Whole-genome sequencing (WGS) was performed to identify biofilm-associated genes and sequence polymorphisms. Biofilm formation and motility phenotypes were assessed, and gene expression ana

SUBMITTER: Wiradiputra MRD 

PROVIDER: S-EPMC12272471 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature