NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection.

ABSTRACT: Natural killer cells (NK) are crucial components of the immune system. NKp30, a significant activation receptor on the NK cell membrane, plays a cytotoxic role by recognizing and binding to corresponding ligands. This interaction mediates the activation of NK cells and the release of regulatory factors, participating in antitumor and anti-infection processes. This review systematically summarizes the structural features and basic functions of NKp30, the impact of N-terminal glycosylation on NKp30 function, related NKp30 ligands and their roles, as well as the antitumor and anti-infective functions and mechanisms of NKp30. The aim is to provide a new perspective for a comprehensive understanding of NKp30 function.

SUBMITTER: Shao Y 

PROVIDER: S-EPMC12272517 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature