Calcium-Dependent S100A8 Amyloid Fibril Formation via S100A1-Mediated Transient Interaction.

ABSTRACT: The S100 family consists of calcium-binding proteins that are largely known for their contribution to neuroinflammatory processes. These proteins are associated with various cardiac and neurological functions as well as related diseases. A few S100 proteins can form unspecific or amyloid aggregates in neuropathologies and thus play a part in dementia pathogenesis. Among all S100 proteins, S100B and S100A9 aggregation properties are the most investigated; however, there is a lack of studies regarding other S100 members. In particular, S100A1 and S100A8 are also associated with neurological pathologies, but their interactions and aggregation are poorly understood. Therefore, in this study, we explored whether S100A1 and S100A8 proteins can form heterodimers, interact, or coaggregate. Our res

SUBMITTER: Karalkeviciute V 

PROVIDER: S-EPMC12272555 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature