PKM2⁺ apoptotic vesicle-mediated systemic senolytics ameliorate chronic periodontitis.

ABSTRACT: Chronic periodontitis (CP) is one of the most prevalent local inflammatory disorders and is associated with various systemic diseases. However, the relationship between local CP pathogenesis and systemic metabolic responses is not fully elucidated. In this study, we show that CP causes systemic inflammation, leading to apoptotic resistance and senescent cell accumulation, which are crucial for maintaining local inflammation in a CP mouse model. Eliminating senescent cells through systemic senolytic therapy ameliorate local CP pathological changes. Proteomic analysis reveals that CP patient plasma extracellular vesicles show upregulation of immune response-related proteins and downregulation of metabolic and apoptosis-related proteins, among which pyruvate kinase M2 (PKM2) was significantly

SUBMITTER: Hao M 

PROVIDER: S-EPMC12272593 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature