Self-powered intracellular nanogenerator attenuates inflammatory osteolysis through mitochondrial MRS2/Mg²⁺-mediated macrophage repolarization and osteoclastogenesis inhibition.

ABSTRACT: Inflammatory bone resorption is present in common oral and maxillofacial diseases. Macrophages play a crucial role in the inflammatory process of bone. It has been shown that M1 macrophages cause bone homeostasis and bone resorption disorders, and M2 macrophage-related cytokines inhibit osteoclast generation. To inhibit inflammatory bone resorption, a method that promotes M2 polarization and inhibits M1 polarization and osteoclastogenesis should be found. Studies have found that the mitochondrial membrane potential of macrophage increases during M2 differentiation, but decreases during M1 differentiation and osteoclast differentiation. Therefore, we hypothesized that it might be possible to use electric fields to regulate macrophage polarization and osteoclast differentiation. Piezoelectri

SUBMITTER: Zuo J 

PROVIDER: S-EPMC12272599 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature