Oral microbiota-regulating and inflammation-targeted polymersome-hydrogels for RNAi therapy of ulcerative colitis.

ABSTRACT: The treatment of ulcerative colitis is harassed by its intricate pathogenesis and the harsh gastrointestinal environment. Herein, oral microbiota-regulating and inflammation-targeted polymersome-hydrogels are developed by incorporating gallic acid and tumor necrosis factor α-specific siRNA-encapsulated polymersomes (GA-siTNFα-PS) into self-healable and eatable hydrogels (SHE-Gel) formed from thiolated sodium alginate and dopamine-modified oxidized inulin (DA-OIn) for oral RNAi therapy of ulcerative colitis. SHE-Gel is stable in stomach, resides in the intestine, and degrades in the colon by colon-specific inulinase. DA-OIn endows SHE-Gel anti-oxidative stress and prebiotic activities that modulate the diversity of gut microbiota. GA-siTNFα-PS released in the colon can adhere to the inflame

SUBMITTER: He H 

PROVIDER: S-EPMC12272602 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature