Prostate radiotherapy in patients with metastatic hormone-sensitive prostate cancer: A systematic review and <i>meta</i>-analysis of randomised controlled trials.

ABSTRACT:

Introduction

The incidence of synchronous metastatic hormone-sensitive prostate cancer (mHSPC) is rising with the increasing use of next-generation imaging. Local radiotherapy (RT) was shown to improve survival in patients with mHSPC; however, new data require a re-assessment of the indication and value of local RT in mHSPC.

Methods

In this prospectively registered systematic review and meta-analysis (CRD42025648251), we searched MEDLINE, Scopus, CENTRAL, and Google Scholar in March 2025 for phase 3 RCTs evaluating the addition of RT to systemic therapy to improve OS in mHSPC patients. Hazard ratios (HRs) were pooled using random-effects meta-analysis. Risk of Bias was assessed with Cochrane's RoB 2 tool.

Results

Out of the 10,615 individual records, we

SUBMITTER: Roessler N 

PROVIDER: S-EPMC12272608 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature