Sonogenetics regulation of intelligent engineered bacteria to reverse immune escape.

ABSTRACT: Cancer immunotherapy resistance significantly challenges its clinical application. Traditional immunotherapy strategies are limited by the difficulty in delivering macromolecular immune modulators into the hypoxic core of tumors, leading to reduced efficacy and the development of resistance. Recently, bacterial-based delivery systems have been identified as a new approach in cancer therapy since bacteria have the potential of penetrating vascular barriers, infiltrating into deep tumor tissues and delivering therapeutics. To enhance the bio-safety and therapeutic efficiency, we developed an ultrasound-controlled, gene-engineered bacterial delivery system in which the bacteria are encapsulated in platelet-liposome hybrid membranes. Upon the application of low intensity focused ultrasound (LI

SUBMITTER: Jiang R 

PROVIDER: S-EPMC12272629 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature