Sex differences in the association between atherogenic index of plasma and α-klotho: insights from a community-based cohort.

ABSTRACT:

Background

The Atherogenic Index of Plasma (AIP) is a marker of lipid imbalance and cardiovascular risk, while α-Klotho is an anti-aging protein involved in oxidative stress and inflammation regulation. Although both are linked to cardiovascular and metabolic health, the relationship between AIP and α-Klotho, particularly regarding sex differences, remains unclear.

Methods

We performed a cross-sectional analysis of a community-based cohort drawn from five consecutive cycles of the NHANES (January 2007 - December 2016). A total of 4,897 participants aged 40 to 79 years were included. Weighted multivariate linear regression models assessed the association between AIP and serum α-Klotho (SαKl) levels, adjusting for demographic and clinical covariates. Sex-stratified analyses ex

SUBMITTER: Tang X 

PROVIDER: S-EPMC12272667 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature