An investigational time-course study using an <i>in vivo</i> ovine laminectomy model for the neurohistopathological evaluation of hemostatic agents.

ABSTRACT:

Background

Preclinical in vivo analysis of hemostatic agents is a fundamental requirement in the assessment of implant safety and efficacy prior to utilization in the clinical operative setting. The purpose of this study served to investigate the hemostatic, peri-operative outcomes and histopathologic responses following epidural application of a novel hemostatic agent in an ovine lumbar laminectomy model. Despite routine utilization of hemostatic agents, the potential for inflammation and compression of neural structures, fibrosis, and neurotoxicity remains a clinical concern. Epidural fibrosis resulting from hemorrhage creates chronic pain and is often refractory to treatment. Experimental endpoints, including intraoperative hemostasis, perioperative neurologic assessment,

SUBMITTER: Day J 

PROVIDER: S-EPMC12272799 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature