Evaluation of Nutraceutical Potential of <i>Carduus marianus</i>: Antioxidant and Hepatoprotective Effects in Paracetamol-Induced Hepatotoxicity and GC-MS Analysis.

ABSTRACT: This study evaluates the hepatoprotective effects of Carduus marianus in a paracetamol-induced hepatotoxicity model using Wistar rats. Wistar rats were divided into six groups and treated with varying doses (100, 200, and 300 mg/kg) of C. marianus 12× aqueous solution after hepatotoxicity induction. Serum biomarkers for liver function (ALT and AST), lipid profiles, renal indicators, oxidative stress markers, and inflammatory mediators were measured. Phytochemical screening revealed alkaloids, glycosides, carbohydrates, saponins, phenols, and flavonoids, with oleic acid as the major component. Gas chromatography-mass spectrometry (GC-MS) identified oleic acid as the predominant constituent (62.96%). Treatment significantly improved liver biomarkers, lipid profiles, and renal f

SUBMITTER: Nasir M 

PROVIDER: S-EPMC12272808 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature