Statin treatment for cerebral small vessel disease: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Cerebral small vessel disease (CSVD) is a chronic, progressive disorder that affects small blood vessels in the brain's white matter. This white matter damage appears on brain imaging as white matter hyperintensities (WMH). Although CSVD is often asymptomatic, it causes one fifth of strokes and nearly half of all vascular dementia cases, highlighting its clinical importance. Statins, widely used to lower lipid levels, are effective for reducing cardiovascular mortality in high-risk groups and are recommended for patients with myocardial infarction and ischemic stroke.

Aim

This systematic review and meta-analysis of randomized controlled trials aimed to evaluate the impact of statin therapy on CSVD.

Method

A literature search was performed in PubMed, Embase,

SUBMITTER: Fresnais D 

PROVIDER: S-EPMC12272895 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature