Phytochemical profiling and anticancer potential of pistachio wastes against MCF-7 breast cancer cells: a metabolic and apoptotic pathway analysis.

ABSTRACT: Food waste poses significant environmental, economic, and social challenges worldwide. Pistachio waste is recognized for its health benefits, particularly for its anticancer properties. This study assessed the phytochemical characteristics of pistachio hull (PH) and shell (PS) using various solvents (ethyl acetate, hexane, and methanol). Methanolic extracts showed substantially higher phenolic and flavonoid contents along with enhanced antioxidant activity across all tested methods, with PH consistently outperforming PS in antioxidant properties. Cell viability tests on MCF-7 cancer cells indicated that PH-Hexane had a slightly greater effect than PH-ethyl acetate and PH-methanol. Cell cycle analysis revealed a notable arrest in the G0/G1 phase compared to the control group. Additionally,

SUBMITTER: Gulum L 

PROVIDER: S-EPMC12272975 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature