Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks.

ABSTRACT:

Background

Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. Developmental enhancers adopt a primed chromatin state prior to their activation. How this primed enhancer state is established and maintained and how it affects the regulation of developmental gene networks remains poorly understood.

Results

Here, we use comparative multi-omic analyses of human and mouse early embryonic development to identify subsets of postgastrulation lineage-specific enhancers which are epigenetically primed ahead of their activation, marked by the histone modification H3K4me1 within the epiblast. We show that epigenetic priming occurs at lineage-specific enhancers for all t

SUBMITTER: Todd CD 

PROVIDER: S-EPMC12272991 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature