Clinical characteristics and prognostic impact of HPV infection in head and neck cancer patients in china: a nationwide multicenter study.

ABSTRACT:

Background

Human papillomavirus (HPV) has emerged as a major cause of head and neck cancer (HNC), yet nationwide HPV-stratified disease data are still lacking in China. The literature remains divided on the prognostic impact of HPV infection.

Methods

The HNC patients treated from 1 January 2017 to 30 June 2021 were retrospectively identified at nine tertiary A centers representing the seven geographic regions of China. Event-free survival (EFS) and cancer-specific survival (CSS) were estimated with the Kaplan-Meier method and compared using the log-rank test. Early survival differences by subsite and HPV status were assessed using restricted mean survival time differences for EFS (ΔRMEFST) and CSS (ΔRMCSST), adjusting for confounders with pseudo-value regression.

Results<

SUBMITTER: Zheng QJ 

PROVIDER: S-EPMC12273054 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature