Assessing grey matter structural alterations in systemic lupus erythematosus using synthetic MRI.

ABSTRACT:

Objectives

To assess brain grey matter alterations in patients with SLE and their correlation with neuropsychological testing using synthetic MRI (SyMRI).

Methods

This prospective study enrolled patients with SLE and age, gender and education-matched healthy controls (HC). Study assessments included brain MRI using SyMRI and neuropsychological tests: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Digit Span Test, Self-Rating Anxiety Scale and Self-Rating Depression Scale (SDS). SyMRI post-processing and Automated Anatomical Labeling were used for grey matter mapping. Correlation analysis was performed to assess the relationship between brain grey matter structural alterations and neuropsychological testing.

Results

77 patients with SLE (57

SUBMITTER: Deng K 

PROVIDER: S-EPMC12273088 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature