Impact of early life antibiotic exposure on the preschool developmental status: a nationwide population-based study.

ABSTRACT:

Objective

Growing concerns exist about the potential adverse effects of early antibiotic exposure on neurodevelopmental outcomes. However, large-scale studies exploring these implications in early childhood are rare.

Design

A nationwide, population-based retrospective cohort study using data from the Korean National Health Insurance System and the National Health Screening Program for Infants and Children (NHSPIC) between 2015 and 2022.

Patients

A total of 1 848 841 children who participated in the NHSPIC at both 4-6 months and 54-60 months of age were included.

Interventions

Antibiotic exposure under 90 days old.

Main outcome measures

Developmental delays in preschool-aged children assessed by the Korean Developmental Screening Test at 54-60 month of ag

SUBMITTER: Kim YK 

PROVIDER: S-EPMC12273155 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature