Aflatoxin exposure and mortality in acutely ill children: results from the CHAIN network cohort.

ABSTRACT:

Background

Chronic exposure to aflatoxins is associated with liver cancer, impaired child growth, and compromised immune function. The Childhood Acute Illness and Nutrition (CHAIN) Network cohort was established to identify risk factors for mortality in acutely ill children admitted to nine hospitals in four African and two South Asian countries. We examined the role of aflatoxin exposure in inpatient and post-discharge mortality.

Methods

In a nested case-cohort from the CHAIN cohort, we compared aflatoxin exposure at admission and discharge with death or survival in hospital (n=755) or up to 180-days post-discharge (n=585) and with community participants (CP, n=222). Children were stratified into non-wasting, medium-wasting and severe-wasting groups based on mid-upper arm c

SUBMITTER: Xia L 

PROVIDER: S-EPMC12273159 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature