Casein sIgE as the most accurate predictor for heated milk tolerance in Finnish children.

ABSTRACT:

Background

Up to 83% of children with cow's milk allergy (CMA) tolerate baked milk, but research on heated milk (HM) tolerance and allergen-specific IgE (sIgE) cutoff values predicting oral food challenge (OFC) outcomes are lacking. We hypothesized that casein sIgE is the best predictor for HM tolerance.

Methods

Finnish children suspected of having IgE-mediated CMA were recruited. sIgE levels to milk, casein, alpha-lactalbumin, beta-lactoglobulin, and bovine serum albumin were measured alongside skin prick tests (SPT) to fresh milk (FM) and HM. The diagnosis was confirmed with an FM OFC. IgE-sensitized children with a positive FM OFC underwent an HM OFC with extensively heated milk in rice porridge. Cutoff values to predict HM OFC outcome were determined, reaction severity a

SUBMITTER: Nieminen O 

PROVIDER: S-EPMC12273190 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature