The FBA solution space kernel: introduction and illustrative examples.

ABSTRACT:

Background

The solution space of an FBA-based model of cellular metabolism, can be characterised by extraction of a bounded, low dimensional kernel (the SSK) that facilitates perceiving it as a geometric object in multidimensional flux space. The aim is to produce an amenable description, intermediate between the single feasible extreme flux of FBA, and the intractable proliferation of extreme modes in conventional solution space descriptions. Fluxes that remain fixed are separated off while the focus of interest is put on the subset of variable fluxes that have a nonzero but finite range of values. For unbounded fluxes, a finite subrange that geometrically corresponds to the variable flux range is determined and is supplemented by a limited set of rays that encapsulates their unbo

SUBMITTER: Verwoerd WS 

PROVIDER: S-EPMC12273201 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature