Maximum cold ischemia duration for a kidney allograft: a prediction model for allograft failure at the time of organ allocation.

ABSTRACT:

Background

Many determinants of kidney allograft failure are established at the time of allocation by organ distribution agencies. At this point, the main modifiable factor is the duration of cold ischemia (CIT). Currently, no practical tool exists to determine the maximum permissible cold ischemia time for a specific recipient at allocation.

Methods

We analyzed two prospective cohorts of kidney transplant recipients from European centers: a derivation cohort of 7040 patients from 10 centers (Barcelona; Leuven; Oslo; Paris Necker, Lyon, Nantes, Nancy, Montpellier, Nice, Paris Saint Louis) with data collected between 2005 and 2020, and a validation cohort of 6131 patients from 6 French centers (Paris Necker, Lyon, Nantes, Nancy, Montpellier, Nice) with data collected between

SUBMITTER: Gosset C 

PROVIDER: S-EPMC12273218 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature