Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study.

ABSTRACT:

Background

Insulin resistance and obesity are significant factors contributing to the incidence of stroke. The present research examines the association between stroke risk and both the triglyceride glucose-weight adjusted waist index (TyG-WWI, a composite marker of insulin resistance and obesity) and its cumulative exposure (CumTyG-WWI).

Methods

A total of 4,718 participants without baseline stroke history were included in this investigation, with new-onset stroke cases identified as the main study outcome. Cumulative exposure to the TyG-WWI was calculated based on repeated measurement data from the first and third waves of the national surveys. The relationships of TyG-WWI and CumTyG-WWI with stroke risk were examined using multivariable Cox regression, followed by validat

SUBMITTER: He S 

PROVIDER: S-EPMC12273225 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature