OSMI-4-based PROTACs do not influence <i>O</i>-GlcNAc transferase and <i>O</i>-GlcNAcylation levels in cells.

ABSTRACT: The O-GlcNAc transferase (OGT) inhibitors disclosed thus far are burdened with certain shortcomings. We have incorporated OSMI-4, a nanomolar OGT inhibitor, into PROTACs. The prepared chimeras failed to induce effective OGT degradation or influence O-GlcNAcylation levels in MM.1S cells.

SUBMITTER: Bricelj A 

PROVIDER: S-EPMC12273342 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature