Genome-wide identification and functional characterization of GPCR family genes reveal their key roles in the vitellarium development and egg production in Schistosoma japonicum.

ABSTRACT:

Background

Schistosomiasis is a zoonotic parasitic disease of the genus Schistosoma. Current therapeutic approaches predominantly rely on the single drug praziquantel, highlighting the urgent need to identify additional effective drug targets. G protein-coupled receptors (GPCRs) play important roles in various biological processes and are considered pivotal in drug development. However, the current understanding of the function of GPCRs in schistosomes remains limited.

Methods

We conducted a systematic bioinformatics analysis of Schistosoma japonicum GPCRs using public genomic resources to elucidate their molecular evolution and expression profiles. Selected GPCRs were functionally characterized using whole-mount in situ hybridization, double fluorescence in situ hybridizati

SUBMITTER: Wang X 

PROVIDER: S-EPMC12273374 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature