Zebrafish models for studying central nervous system effects of Ayurvedic medicinal plants.

ABSTRACT: Traditional Indian medicine (Ayurveda) has a long history of treating central nervous system (CNS) disorders. Ayurvedic plants are typically rich in flavonoids, lignans, sterols, tannins and alkaloids that exert potent anti-inflammatory, anti-oxidant, neuroprotective and neurotropic effects in both humans and rodents. The zebrafish (Danio rerio) has emerged as a useful model species and a powerful vertebrate in vivo system for CNS disease modeling and drug screening. As zebrafish continue to demonstrate their growing utility for studying a wide range of pharmaceutical therapies, including Chinese and American traditional medicines, here we discuss CNS effects of various Ayurvedic medicinal plants, and how they can be further elucidated using zebrafish models. We also evaluate the existing

SUBMITTER: Chakraborty P 

PROVIDER: S-EPMC12273437 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature