Individualized transcranial temporal interference stimulation (tTIS) for cognitive impairments and negative symptoms in patients with schizophrenia: a study protocol for a randomized controlled trial.

ABSTRACT:

Background

Cognitive deficits and negative symptoms are core features of schizophrenia (SCZ) and remain major therapeutic challenges due to their limited responsiveness to antipsychotic medications. Transcranial temporal interference stimulation (tTIS) is a novel, non-invasive brain stimulation technique that enables targeted modulation of deep brain structures with high spatial specificity. While tTIS has shown promise in preliminary studies of other neuropsychiatric conditions, its clinical utility in SCZ has not been established. This study aims to evaluate the safety and efficacy of tTIS targeting the right nucleus accumbens (NAc) in ameliorating cognitive deficits and negative symptoms in SCZ individuals.

Methods

In this randomized, double-blind, controlled trial, 76 SC

SUBMITTER: Wang S 

PROVIDER: S-EPMC12273462 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature