Functional-structural co-dependent brain mapping of metamemory in amnestic mild cognitive impairment.

ABSTRACT:

Background

Metamemory, a measure of introspective awareness of memory performance, provides an internally-generated drive, profoundly impacting external memory activities. Given its role in regulating memory along internal-external axis, understanding metamemory and underlying neural mechanisms in amnestic mild cognitive impairment (aMCI) is crucial for memory improvement. The present study was aimed to explore metamemory alterations and structural and functional remodeling characteristics underlying metamemory, as well as key brain regions that potentially moderated its intrinsic associations with age, education, and first-order cognition in aMCI.

Methods

Sixty-seven aMCI patients and fifty-two healthy controls underwent neuropsychological assessments and magnetic resonance

SUBMITTER: Lu JJ 

PROVIDER: S-EPMC12273479 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature