Exercise preconditioning alleviates photothrombotic ischemic stroke in mice by orchestrating neutrophils.

ABSTRACT:

Background

In ischemic stroke (IS) pathology, neutrophils are rapidly recruited to the infarcted brain and exacerbate tissue damage by releasing the amount of neutrophil extracellular traps (NETs). Previous studies have demonstrated that alleviating IS is associated with reduced accumulated neutrophils and NET levels. Notably, exercise preconditioning (EP) has the potential to modulate neutrophil function, thereby contributing to the amelioration of IS. This study compared the functional differences between resting and EP-induced neutrophils under IS pathology.

Methods

Eight-week-old C57BL/6J male mice underwent 8 weeks of voluntary exercise before photothrombotic ischemic stroke (PTI) surgery. Behavioral tests were conducted 2 days after PTI to verify the effects of EP on a

SUBMITTER: Kim TY 

PROVIDER: S-EPMC12273507 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature