Three-dimensional cellular construct with impregnated silicon nanowires for intracellular optoelectronic biointerface.

ABSTRACT: Three-dimensional tissue models are considered a more comprehensive replica of the in vivo microenvironment than their traditional monolayer counterparts. Therefore, tissue engineering methods have the potential to revolutionize biomedical research by allowing researchers to shift away from animal models while improving model relevance. However, while state-of-the-art electrical devices can perturb the biophysical cell niche in 2D monolayers, the biomodulation "toolkit" available for 3D application does not meet the required level of complexity, specificity, and accuracy, limiting the ability to perform intracellular electrical modulation of cells inside 3D cellular constructs. In this work, a 3D e-scaffold impregnated with free-standing silicon nanowires was developed to enable local and

SUBMITTER: Hathot N 

PROVIDER: S-EPMC12273512 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature