Demographics of lipoprotein(a) and stroke: The UK biobank.

ABSTRACT:

Introduction

Lipoprotein(a) [Lp(a)] is associated with ischemic stroke, but the strength of association based on demographic differences remains unclear. We aimed to investigate the association between Lp(a)>125 nmol/L and stroke by age, sex, and racial/ethnic subgroups.

Methods

Using data from the UK Biobank, we included 353,309 participants with an Lp(a) measurement without a history of atherosclerotic cardiovascular disease (ASCVD). Stroke was defined as ischemic stroke or hemorrhagic stroke (with subtypes subarachnoid hemorrhage and intracerebral hemorrhage). Cox proportional hazards models were used to evaluate the association between elevated Lp(a) and stroke (ischemic or hemorrhagic), adjusted for ASCVD risk factors, race/ethnicity, lipid lowering therapy, antiplatele

SUBMITTER: Kao AS 

PROVIDER: S-EPMC12273577 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature