Prognostic value of tumor-infiltrating lymphocytes in irradiated node-positive breast cancer patients.

ABSTRACT:

Introduction

Radiotherapy significantly reduces locoregional recurrence (LRR) and improves survival. Yet, reliable biomarkers predicting radiotherapy response are not well-defined. Tumor-infiltrating lymphocytes (TILs) have emerged as a promising prognostic and predictive marker, but their role in irradiated patients remains underexplored.

Methods

This case-cohort study included 1461 node-positive, irradiated breast cancer patients from the Danish Breast Cancer Group (DBCG) internal mammary node (IMN)2 study. IMN irradiation (IMNI) was allocated by tumor laterality. TILs were assessed in treatment-naïve primary tumors and dichotomized using a 30 % cut-off. Endpoints included overall mortality (OM), breast cancer-specific mortality (BCM), distant recurrence (DR), and LRR. Fle

SUBMITTER: Ozcan D 

PROVIDER: S-EPMC12273579 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature