Neuronally-Derived Extracellular Vesicles Transforming Growth Factor Beta-1 Levels in Progressive Supranuclear Palsy.

ABSTRACT:

Background

Differentiating progressive supranuclear palsy (PSP) from other parkinsonian disorders may be challenging.

Objectives

To investigate the role of transforming growth factor beta-1 (TGFβ1) in PSP.

Methods

A total of 33 PSP, 39 Parkinson's disease (PD), 8 multiple system atrophy (MSA) patients, and 50 healthy controls (HC) were enrolled. TGFβ1 levels, including both active and inactive forms (latency-associated peptide [LAP]-TGFβ1), were measured in serum, total extracellular vesicles (EVs), and neuronally-derived EVs (NDEVs) using microfluidic assays and ELISA.

Results

PSP patients exhibited a marked increase in TGFβ1 and LAP-TGFβ1 levels in NDEVs, while no differences were observed across groups in serum or total EVs. Receiver operating characteristic

SUBMITTER: Mimmi S 

PROVIDER: S-EPMC12273611 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature