A Parameterized Cross-Sectional Model for Simulating Balloon Angioplasty in Atherosclerotic Arteries.

ABSTRACT: Atherosclerotic arteries exhibit geometric alterations due to plaque deposition, which often leads to luminal narrowing. Balloon angioplasty is a common and suggested treatment to restore blood flow. However, depending on balloon oversizing, rupture at the plaque shoulder or the fibrous cap may occur. The rupture risk is influenced by factors such as the geometry of the fibrous cap, the lipid pool size, and calcifications. Despite advances in clinical imaging, predicting plaque rupture remains challenging because of lesion variability. This study addresses this gap by identifying key geometrical factors that influence stress distribution during balloon angioplasty, thus improving biomechanical insights and risk assessment. In this work, we develop a parameterized cross-sectional model of t

SUBMITTER: Kwakman SMB 

PROVIDER: S-EPMC12273774 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature