Architecture mechanics mediated osteogenic progression in bone regeneration of artificial scaffolds.

ABSTRACT: Scaffold architecture exerts a considerable influence on the osteogenic effect through stress transmission, as the deformation of scaffolds alters the mechanical microenvironment of cells adhering to scaffold surface. Despite extensive research on bone regeneration influenced by scaffold architecture, present studies have not addressed the biological mechanism underlying scaffold architecture-induced stress stimulation (SASS) on cells yet, posing a great challenge in revealing the biomechanical cues between scaffold architecture and osteogenic progression. Therefore, graphite, fullerene, and diamond scaffolds with gradient stress stimulation to cells after deformation were prepared. The cellular biomechanical mechanisms of SASS through single-cell RNA sequencing indicated that architecture

SUBMITTER: Long SY 

PROVIDER: S-EPMC12273797 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature