Mettl3 Regulates Lens Development by Promoting the Differentiation Processes of Secondary Fiber Cells.

ABSTRACT:

Purpose

Lens development requires tight regulation of cell proliferation and differentiation processes, the disruption of which might lead to congenital cataract formation. N6-methyladenosine (m6A) is the most prevalent mRNA internal modification and has been shown to play important roles in regulating the development, physiology, and pathology of various organs and tissues. However, the function of m6A during lens development remains unknown. The purpose of this study was to investigate the function of Mettl3, the core catalytic component of the m6A-writer complex, during lens development.

Methods

Lens-specific Mettl3 conditional knockout (Mettl3-CKO) mice were used as a model to investigate the function of Mettl3 during lens development. Hematoxylin and eosin staining was

SUBMITTER: Hu L 

PROVIDER: S-EPMC12273886 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature