3D finite element models reveal regional fatty infiltration modulates tibialis anterior force generating capacity in FSHD.

ABSTRACT: Facioscapulohumeral muscular dystrophy (FSHD) is a progressive neuromuscular disorder characterized by muscle damage, fibro-fatty infiltration, and ultimately weakness. The tibialis anterior (TA), very often involved relatively early in FSHD, is a primary dorsiflexor and important for ambulation. Recent work using magnetic resonance imaging to quantify fat infiltration in the TA volume observed a steep decline in force generation after fat reached ~20% in volume. Additional imaging studies have identified regional fat infiltration patterns that may contribute to the non-linear relationship between fat volume and muscle strength due to the distribution of fat within the muscle structure. The goals of this study were to 1) develop a pipeline for creating subject-specific models of the TA tha

SUBMITTER: McCrady A 

PROVIDER: S-EPMC12273932 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature