Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal hippocampus.

ABSTRACT: Acute moderate-intensity exercise (AME) after learning has been reported to exogenously boost consolidation of hippocampus-dependent memory, resulting in improved long-term persistence. However, the neuronal mechanism remains poorly understood. Short-term, hippocampus-dependent memory produced by weak encoding can be transformed into long-term memory through an immediate, strong behavioral event, which causes overlapping activation of the hippocampus. Hippocampal de novo protein synthesis is essential for achieving memory consolidation in this way. As AME activates the hippocampus, enhanced memory consolidation through post-learning AME may also be mediated by protein synthesis in the hippocampus. To test this hypothesis, this study first attempted to establish a rat model for enhancing me

SUBMITTER: Inoue K 

PROVIDER: S-EPMC12273956 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature