Mechanistic investigation of glycolysis and pyroptosis in colon adenocarcinoma tissues, and prognostic analysis of patient clinical outcomes.

ABSTRACT:

Background

The exact mechanisms driving colorectal cancer (CRC) are yet to be fully elucidated. This study aims to confirm the reliability of a prognostic model for colon adenocarcinoma (COAD) by analyzing the varied expression levels of Glycolysis & Pyroptosis-Related Differentially Expressed Genes (G&PRDEGs) in COAD using bioinformatics tools.

Methods

We retrieved gene expression data and clinical details for COAD patients from the Cancer Genome Atlas (TCGA) database. These data were analyzed to categorize the samples into pyroptosis-positive and pyroptosis-negative groups based on their expression of G&PRDEGs. A prognostic model for COAD was then developed using LASSO Cox regression analysis, focusing on these differentially expressed genes (DEGs). Kaplan-Meier curves wer

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12273967 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature