Semaphorin 3f and post-embryonic regulation of retinal progenitors.

ABSTRACT: Neural progenitors produce specific cell types that form the circuits of the nervous system. Extrinsic signals regulate both progenitor proliferation and the production of specific neuron types. Where progenitors reside within a progenitor niche determines to which of these signals they are exposed, and thus likely has important consequences on the progeny they produce. Little is known, however, of the signals that govern progenitor location within the niche. Here we show that a member of the Class III family of secreted Semaphorins, Semaphorin3fa (Sema3fa), is required for the orderly arrangement of progenitors with a niche present in the periphery of the larval and adult retina of zebrafish, the ciliary marginal zone (CMZ). CMZ progenitors express mRNAs for various Sema3 receptors, inclu

SUBMITTER: Kalifa A 

PROVIDER: S-EPMC12274001 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature