Mediodorsal thalamic nucleus mediates resistance to ethanol through Ca_v3.1 T-type Ca²⁺ regulation of neural activity.

ABSTRACT: Thalamocortical activity is known to orchestrate sensory gating and consciousness switching. The precise thalamic regions involved, or the firing patterns related to the unconsciousness, remain unclear. Interestingly, the highly -expressed thalamic T-type calcium currents have been considered as a candidate for the ionic mechanism for the generation of thalamocortically driven change in conscious state. Here, we tested the hypothesis that Ca_v3.1 T-type channels in the mediodorsal thalamic nucleus (MD) might control neuronal firing during unconsciousness using Ca_v3.1 T-type channel knockout (KO) and knockdown (KD) mice under natural sleep and ethanol-induced unconsciousness. During natural sleep, the MD neurons in KO mice showed general characteristics of sustained fir

SUBMITTER: Latchoumane CV 

PROVIDER: S-EPMC12274065 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature