YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2.

ABSTRACT:

Background

Parkinson's disease (PD) is a common neurodegenerative movement disorder, mainly characterized by the degeneration and loss of dopaminergic neurons in the substantia nigra. Oxidative stress is considered to be a key contributor to dopaminergic neuronal degeneration, triggering a series of downstream events such as mitochondrial dysfunction, neuroinflammation and misfolded protein aggregation, which ultimately exacerbate the development of PD. Deubiquitinating enzymes (DUBs) regulate oxidative stress, but their roles in PD remain unclear.

Methods

GEO database analysis and western blotting were used to analyze the expression of YOD1in PD patients and PD mouse models. Genetic knockout (KO) of YOD1 was performed to assess its effects in PD pathogenesis. The substance

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12274113 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature