<i>Setaria viridis</i> Ethanol Extract Attenuates Muscle Loss and Body Fat Reduction in Sarcopenic Obesity by Regulating AMPK in High-Fat Diet-Induced Obese Mice.

ABSTRACT: Sarcopenic obesity, characterized by the concurrent presence of sarcopenia and obesity, presents a complex challenge due to the synergistic detrimental effects of muscle loss and excess body fat. This study investigated the potential of Setaria viridis (SV) supplementation for mitigating the impact of sarcopenic obesity on diet-induced obese mice. Mice in the study were divided into groups and fed a normal diet, a high-fat diet (HFD), or an HFD supplemented with 0.3% SV ethanol extract. After 16 weeks, SV supplementation significantly reduced body weight gain and white adipose tissue mass, improved plasma lipid profiles, and preserved liver function without affecting food intake. Additionally, SV enhanced skeletal muscle mass and hind-limb thickness, and restored anabolic signaling

SUBMITTER: Kwon EY 

PROVIDER: S-EPMC12274159 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature