<i>Polygonati Rhizoma</i> Polysaccharides Ameliorated Diabetic Kidney Disease in <i>db/db</i> Mice via Inhibiting TGF<i>β</i>/Smad2 Signaling Pathway.

ABSTRACT: Polygonati Rhizoma polysaccharides (PP) are the active components isolated from medicine food homology (MFH) Chinese herb Polygonati Rhizoma. Diabetic kidney disease (DKD) is a serious diabetic complication occurring in the later stage of diabetes. We have previously reported the hypoglycemic effect of PP on early-stage type 2 diabetes (T2D). This study evaluated the effect of PP on DKD and investigated the underlying mechanisms. PP was mainly composed of L-fucose, L-rhamnose, D-glucose, and D-mannose. Ten-week-old Leprdb/Leprdb (db/db) compared with control Leprdb/Lepr+ (db/+) mice were given vehicle or PP for 16 weeks. Our results showed that PP alleviated renal dysfunction (BUN, Cr, microalbumin) and pathological damage in db/db mice. PP improve

SUBMITTER: Mei X 

PROVIDER: S-EPMC12274161 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature