Identification of biomarkers for Laryngeal squamous cell carcinoma through Mendelian randomization and integrated bioinformatics analysis.

ABSTRACT:

Background

Laryngeal squamous cell carcinoma (LSCC) is a common head and neck tumor with an increasing incidence rate and limited therapeutic efficacy in advanced stages.

Methods

This study integrated multi-omics data from multiple databases to comprehensively analyze the role of pan-apoptosis-related genes (PANRGs) in the prognosis of LSCC. RNA-seq data from 114 LSCC and 12 normal samples were collected from the TCGA-HNSC cohort as a training set, while 270 LSCC samples were obtained from the GSE65858 dataset as a validation set. Additionally, copy number variation (CNV) data were retrieved from the UCSC Xena database, and single-cell RNA sequencing (scRNA-seq) data from two LSCC samples were obtained from the GSE150321 dataset. Differential expression analysis was performe

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12274188 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature