Impact of leukoreduction on the metabolome of ovine packed red blood cells during refrigerated storage.

ABSTRACT:

Background

Blood transfusion is a life-saving intervention for many species of veterinary interest, including sheep. Despite extensive research on the impact of refrigerated storage of packed red blood cells (pRBC) in humans, research on the quality of stored ovine blood is limited and storage guidelines are mostly informed by studies in humans. Human pRBC are currently stored without residual white blood cells, following selective removal of the leukocytes by filtration (leukoreduction). This process delays the onset and mitigates the progression of the storage lesion, a series of molecular changes that RBC undergo as a function of storage duration. However, leukoreduction of ovine pRBC is not routinely performed.

Materials and methods

Here we performed metabolomics analyse

SUBMITTER: Miglio A 

PROVIDER: S-EPMC12274201 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature