Identification of a Novel Gene ARNT2 for Osteogenic Differentiation of Mesenchymal Stem Cells.

ABSTRACT: The balance between adipogenesis and osteogenesis in mesenchymal stem cells (MSCs) is pivotal for the maintenance of bone homeostasis. However, the genes responsible for regulating this balance are still not fully understood. This investigation sought to explore and identify novel genes that influence MSC differentiation into adipogenic and osteogenic lineages, thereby enhancing bone formation. Four datasets from the Gene Expression Omnibus (GEO) database were utilized: three focused on osteogenic differentiation (GSE73087, GSE18043, GSE114117), and one on adipogenic differentiation (GSE37836). Differentially expressed genes (DEGs) during both osteogenic and adipogenic differentiation processes were analyzed using the limma R package. A sum of 471 common differentially expressed genes (CDE

SUBMITTER: Ding M 

PROVIDER: S-EPMC12274243 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature